I purchased both the Lowepro and a Swissgear 1900 Scansmart at the same time and compared them side by side. My DIL has a Lowepro for her professional photography business and loves it and suggested that I take a look a the Lowepro for my laptop needs.
The Lowepro is about three inches narrower but three inches taller and feels easier to move around without bumping into anything or anyone. The Lowepro has a much larger central storage area for larger items and will easily be adequate for overnight trips, at least in the summer. It has an additional inch of expansion with a zipper on three sides of the bag. The main storage space has a "false" bottom that is attached by velcro that can also be removed for more storage space or to store your shoes in. The pouch which normally fits under this velcro bottom can be easily moved to molle loops on the back of the pack and comes with the needed strap. There are also a couple more rows of molle loops on the back of the pack that can be used for additional pouches, available on Amazon of course, for even more storage.
Here's what I thought Swissgear does better: Their handle at the top of the bag is definitely more substantial and appears to be attached better. Swissgear also has a "locker" loop for hanging in bathroom stalls that appears to be pretty handy. Lastly, Swissgear has their Scansmart feature which allows you to unzip the laptop portion of the bag and lay it flat for x-raying at TSA, in theory saving you from removing the laptop from the bag. While this is a great feature, most of my trips are by car so it was less useful for me.
The construction, material, number of pockets, backstraps and price seemed to be about equal between the bags. The Lowepro has a different profile but is a great bag if you can get past that.
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